Yes, this feature is available for WP Ghost.
It works with both structures of WP Multisite: subdomain & subdirectories.
WP Ghost works on WP Multisite and you will configure it for the entire network.
Multisite counts just as one site. Because the settings and usage will happen in Network > Plugins, and not on each individual site.
The Ghost Mode also works with Apache, Nginx, IIS and LiteSpeed servers.
Read More: Customize Paths with WP Ghost